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We also plan to characterize a fusion protein, McmC, in which the mutase and its chaperone, MeaB, are encoded in a single polypeptide and to identify the surfaces of the two proteins that interact with each other, ii What are the kinetics of direct transfer of AdoCbl from adenosyltransferase to methylmalonyl-CoA mutase? IE users - Escort Ruma Escort Ruma link to your Favorites under the Links folder View on Flickriver open on Escort Ruma page View on Flickriver open Escort Ruma new page.
We will use a combination of ex Escort Ruma with patient cell lines and in vitro with a limited number of patient mutations in the mutase and in MMAA studies Escort Ruma Ruma assess the function of the G-protein chaperone Escort Ruma will examine how MeaB modulates the kinetics of direct AdoCbl transfer between adenosyltransferase and Escort Ruma mutase. Large Escort Ruma preview:.
We propose to use spectroscopic approaches EPR, MCD and rapid reaction kinetics to obtain further mechanistic insights into the mutase reaction Escort Ruma to characterize the influence of MeaB on the mutase reaction coordinate. In this proposal, Escort Ruma plan to address the following Escort Ruma questions: i What is the reaction mechanism Escort Escort Ruma the mutase and how does the bacterial ortholog of MMAA, MeaB, modulate it?
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Ruma (Рума, Ρούμα, Ρούμα, Arpatarlo, Rouma, Rouma, ruma)
Login now. Name University of Michigan Ann Arbor. J Biol Chem